You will find there's launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to lower afferent ache transmission and create analgesia. Thus, medicines like clonidine that focus on alpha-2 receptors can impact the transmission of pain. Among the list of theories https://isaacq479tqj7.tdlwiki.com/user