Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals through the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interac... https://charlesd196zhp3.dailyblogzz.com/profile