The impairment of HMGB1 functionality results in increased mitochondrial DNA damage. In the SCA1 mouse model, more than-expression on the HMGB1 protein by means of an introduced virus vector bearing the HMGB1 gene facilitates restore on the mitochondrial DNA problems, ameliorates the neuropathology as well as motor deficits, and extends https://angelocfjnq.blogchaat.com/28321548/about-isa-2011b